J Rymaszewska , K M Urbanska , D Szczesniak , B Stanczykiewicz , E Trypka , A Zablocka
Background: Mild Cognitive Impairments (MCI) and dementia are still incurable. The
Whole-Body Cryotherapy (WBC) – short, cyclic exposure to extremely low temperatures
– has proven anti-inflammatory and anti-oxidative effects. It can also induce hormonal,
lipid and neural changes.
Objective: To evaluate the WBC effect on cognitive functioning and blood parameters
of MCI patients.
Materials and methods: Participants with MCI undertook 10 WBC sessions. Cognitive
functions and depressive symptoms were assessed before the first session, after the
last session and 2 weeks later. Whole blood samples were collected.
Results: The cognitive functioning improved after 10 WBC sessions (p<0.05),
especially memory processes. WBC caused a significant (p<0.05) increase of NO
plasma level, BDNF concentration (p<0.05) and reduction of IL-6 (p<0.05). The
moderate relationship between NO and cognitive functioning was noticed after WBC.
Conclusion: The preliminary results of the first study evaluating WBC on memory
deficits suggest that WBC may be useful as a supportive therapy of MCI.
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